A turning point in the world of contraception that may soon no longer burden on women thanks to the YCT-529, a male contraceptive pill that does not resort to hormones
A revolution in male contraception could become reality by 2030. This is the Yct-529an experimental drug that, for the first time, It acts on male fertility Without resorting to hormones, opening the way to a new contraceptive option for men, up to now practically non -existent.
To develop the mixture is Yourchoice Therapeutics, in collaboration with the University of Minnesota and Columbia University. Unlike the female pill, which regulates hormones to inhibit ovulation, the Yct-529 acts on a specific protein linked to male fertility, in particular blocking the Rar-Alfa receptors of vitamin Afundamental for the Spermatozoa production.
High effectiveness and reversibility
In preclinical tests the drug has shown an effectiveness of the 99% in preventing pregnancieswithout causing significant side effects. A fundamental aspect is the reversibility: fertility has returned to normal within 6 weeks in the rodents and between 10 and 15 weeks in the primates after suspension of the treatment. This indicates a Safe contraceptive potential, temporary and non -invasive contraceptivean absolute novelty in the panorama of male health.
The first clinical study on man was successfully completed in the 2024showing that the drug is also well tolerated in humans. Currently the phase II of experimentationwith a greater number of participants, men between 28 and 70 years of age, to deepen effectiveness and safety with higher doses.
Greater equity in contraceptive liability
The availability of the male contraceptive pill would mark an important step also on a social level, favoring one greater equity in contraceptive liability. At the moment the only two options approved for men are condoms and vasectomy, while most contraceptives still burns on women.
The CEO of Yourchoice, Akash Bakshi, said that the interest by men is high, testifying to a change in the perception of fertility and shared family planning. If the next results confirm what has been observed so far, the Yct-529 it could really become the first non -hormonal male pill on the marketrevolutionizing the way we conceive contraception in the 21st century.
