Recent research has revealed how the Mediterranean diet is effective in improving survival rates and response to immunotherapy in patients with advanced melanoma. The data showed the effectiveness of the Mediterranean diet rich in fibre, polyphenols and good fats
There Mediterranean diet already celebrated for its numerous benefits on cardiovascular and metabolic health, it could prove to be one also a powerful ally in the fight against cancer. According to a recent study published by the University of Groningen, a diet rich in fibre, monounsaturated fatty acids and polyphenols was associated with better response rates toimmunotherapy and to increased survival in patients with melanoma advanced.
A strategic nutrition for Immunotherapy
Experts noted that the Mediterranean diet could play a key role in the success ofimmunotherapypaving the way for new research aimed at evaluating its effects on other types of tumors, including those of the digestive system.
But what makes this diet so special? The secret seems to lie inperfect balance between mono and polyunsaturated fats present in olive oil, nuts and fish, and the high content of polyphenols and fibers from fruit, vegetables and whole grains. According to research, these elements would be able to significantly improve the response to immunotherapy drugs called Immune Checkpoint Inhibitors (ICI).
ICIs are innovative drugs that have revolutionized the treatment of melanoma, acting directly on immune system checkpoints and pushing T lymphocytes to attack tumor cells.
The study
The multicenter study conducted by researchers from the United Kingdom and the Netherlands involved 91 patients with advanced melanoma. Their diet was carefully monitored during treatment with ICI, and the results showed that those who followed a Mediterranean diet had a more effective response to the therapy.
Laura Bolte, author of the study and doctoral student under the supervision of Prof. Rinse Weersma of theUniversity Medical Center GroningenNetherlands, commented:
ICI drugs have helped revolutionize the treatment of several types of advanced cancers. Our study highlights the importance of dietary assessment in cancer patients, initiating ICI treatment, and supports the role of dietary strategies to improve outcomes and survival.
The study also found that eating whole grains and legumes reduced the likelihood of developing drug-induced immune-related side effects, such as colitis; in contrast, red and processed meat was associated with a greater likelihood of side effects.
The relationship between ICI response with diet and the gut microbiome opens up a promising and exciting future for improving treatment responses. Clinical trials are underway to study the effect of a high-fiber diet, ketogenic diet, and omega-3 supplementation. As ICI therapy is expanded to various tumor types, including digestive cancers, these studies could unlock the benefits of the treatment for a large group of cancer patients.
Microbiome and cancer: a promising future
The link between diet, intestinal microbiome and immune response is one of the most exciting aspects of oncology research. The connection between nutrition and ICI response suggests a future full of potential for improving the effectiveness of cancer therapies.
Currently, new clinical studies are underway to investigate the role of other dietary regimes, such as the ketogenic diet and omega-3 supplementation, in the response to immunotherapy treatments. As ICI therapy expands to a growing number of cancers, including those of the digestive system, these findings could open up new avenues for improving the quality of life and recovery prospects of a large number of patients.
In conclusion, this research only reinforces the concept that a healthy diet not only prevents many diseases, but can also become a powerful weapon to fight cancer. Following a Mediterranean diet could not only improve general well-being, but also enhance the effectiveness of the most advanced therapies, offering new hope to cancer patients around the world.
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